Local Intra-Arterial Drug Delivery for Prevention of Restenosis
| Autor: | Ute Brehme, Ludger Dinkelborg, Marc Kalinowski, Claus D. Claussen, Roland Bares, Andreas Baumbach, Hartmut Hanke, Joachim Kamenz, G. Tepe, Stephan H. Duda |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Pertechnetate Arteriosclerosis Balloon Catheterization chemistry.chemical_compound Restenosis Pharmacokinetics Recurrence medicine Animals Radiology Nuclear Medicine and imaging Gamma counter business.industry Balloon catheter General Medicine medicine.disease Injections Intra-Arterial chemistry Drug delivery Rabbits Radiology Radiopharmaceuticals Endothelin receptor Nuclear medicine business |
| Zdroj: | Investigative Radiology. 36:245-249 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/00004424-200105000-00001 |
| Popis: | rationale and objectives. Several radiopharmaceuticals were administered through a porous balloon catheter to compare the absolute amount deposited and the retention in the vessel wall. The reported efficiency of local drug delivery ranges from 0.001% to 0.1%, with poor retention after 24 hours. methods. An endothelin derivative (n = 6), pertechnetate (n = 6), hexamethylpropylene amineoxime (HMPAO) (n = 5), ethyl cysteinate dimer (ECD) (n = 5), and tin colloid (n = 5) were labeled with 185 MBq/mL 99m-technetium. After balloon denudation of the infrarenal aorta in 27 New Zealand White rabbits, 100 μL of each agent was administered through a porous balloon at a pressure of 4 bar. Dynamic and static whole-body scintigrams were obtained for 24 hours. The infrarenal aorta was excised and the activity calculated in a gamma counter. results. Apart from their retention in the region of local administration, the radiopharmaceuticals showed different distribution patterns. The highest regional tracer retention was observed with HMPAO. After administration of HMPAO, a significant difference between regional (vessel wall plus surrounding tissue: 14.5% of injected dose [ID]/24 hours) and local (vessel wall: 1.8% ID/24 hours) delivery was found. In contrast, ECD was eliminated quickly (local retention after 24 hours = 0% ID). The retention efficiencies were HMPAO > endothelin derivative > tin colloid > pertechnetate > ECD. conclusions. The different physicochemical and pharmacokinetic properties of radiopharmaceuticals resulted in different delivery efficiencies after local application. |
| Databáze: | OpenAIRE |
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