Effects of starvation and obesity on somatostatin, insulin, and glucagon release from an isolated perfused organ system
| Autor: | C. A. Baile, F. M. Matschinsky, G. Boden, C. L. McLaughlin |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Physiology Tolbutamide Endocrinology Diabetes and Metabolism medicine.medical_treatment Stimulation Glucagon Islets of Langerhans Physiology (medical) Internal medicine Insulin Secretion medicine Animals Insulin Obesity Amino Acids Starvation Chemistry Glucagon secretion Fasting Rats Rats Zucker Glucose Somatostatin Endocrinology Basal (medicine) medicine.symptom hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 241:E215-E220 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1981.241.3.e215 |
| Popis: | We have studied the effects of starvation and of obesity on somatostatin, insulin, and glucagon release from an isolated perfused organ system in fed and 3- and 5-day fasted Holtzman rats and in obese (fa/fa) and lean (Fa/?) Zucker rats. Fasting for 3 days significantly decreased basal (-71%) and amino acid-stimulated (-62%) somatostatin output. After 5 days of starvation, there was a significant increase over the 3-day level in somatostatin output stimulated by amino acid plus glucose (+540%) and by amino acids plus tolbutamide (+238%). Three and five days of starvation severely depressed insulin output while having no statistically significant effects on glucagon secretion. Somatostatin output from obese Zucker rats was significantly greater than that from lean controls in response to amino acids (41.2 +/- 13.2 vs. 16.3 +/- 10.3 ng/25 min, P less than 0.05). Insulin output was greatly increased from obese compared to lean Zucker rats, whereas there were no statistically significant differences in glucagon output. These data show that fasting decreases and obesity increases both somatostatin and insulin release. They suggest that altered stimulation by nutrients was primarily responsible for changes in somatostatin and insulin release observed in starving and obese rats. |
| Databáze: | OpenAIRE |
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