Prosthetic valve endocarditis caused by Bordetella holmesii, an Acinetobacter lookalike
| Autor: | Annelies De Bel, Stijn Jonckheere, Oriane Soetens, Ignace Surmont, Thierry De Baere, Pascal Schroeyers |
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| Přispěvatelé: | Immunology and Microbiology, Microbiology and Infection Control |
| Rok vydání: | 2012 |
| Předmět: |
Adult
DNA Bacterial Male Microbiology (medical) Aortic valve Prosthesis-Related Infections Bordetella medicine.medical_treatment Molecular Sequence Data Tigecycline DNA Ribosomal Microbiology Tazobactam Valve replacement RNA Ribosomal 16S Humans Medicine Endocarditis Bordetella Infections Bordetella holmesii biology business.industry Endocarditis Bacterial Sequence Analysis DNA General Medicine Acinetobacter medicine.disease biology.organism_classification Anti-Bacterial Agents medicine.anatomical_structure Infective endocarditis business medicine.drug |
| Zdroj: | Journal of Medical Microbiology. 61:874-877 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/jmm.0.038695-0 |
| Popis: | We report a case of fulminant endocarditis on a prosthetic homograft aortic valve caused by Bordetella holmesii, which was successfully managed by surgical valve replacement and antibiotic treatment. B. holmesii, a strictly aerobic, small, Gram-negative coccobacillus, has been implicated as an infrequent cause of a pertussis-like syndrome and other respiratory illnesses. However, B. holmesii is also a rare cause of septicaemia and infective endocarditis, mostly in immunocompromised patients. To our knowledge, this is the first report of B. holmesii endocarditis on a prosthetic aortic valve. Routine laboratory testing initially misidentified the strain as Acinetobacter sp. Correct identification was achieved by 16S rRNA gene and outer-membrane protein A (ompA) gene sequencing. Interestingly, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry also produced an accurate species-level identification. Subsequent susceptibility testing and review of the literature revealed ceftazidime, cefepime, carbapenems, aminoglycosides, fluoroquinolones, piperacillin/tazobactam, tigecycline and colistin as possible candidates to treat infections caused by B. holmesii. |
| Databáze: | OpenAIRE |
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