Role of the Fas/Fas ligand system in female reproductive organs: survival and apoptosis
| Autor: | Marijke Kamsteeg, Shawn Straszewski, Gil Mor |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Programmed cell death
Fas Ligand Protein Cell Survival Genital Neoplasms Female medicine.drug_class Cell Apoptosis Ovary Biology Biochemistry Fas ligand Mediator medicine Animals Homeostasis Humans Macrophage fas Receptor Pharmacology Membrane Glycoproteins Macrophages Reproduction medicine.anatomical_structure Estrogen Cancer research Female |
| Zdroj: | Biochemical Pharmacology. 64:1305-1315 |
| ISSN: | 0006-2952 |
| Popis: | For centuries, the question of "whether there is life after death" has intrigued the mind of philosophers and the same question fascinates researchers in the field of apoptosis today. The death of a cell is by no means the end of the story. On the contrary, growing evidence suggests that the clearance of apoptotic bodies by macrophages is an important regulatory component in tissue renewal. Without death by apoptosis, the life of reproductive tissues and their function would not be possible. The survival signals that counteract cell death also prepare the cells for apoptosis, and dead cells are important stimuli for tissue survival. The Fas/Fas ligand system is an important mediator of apoptosis and is an excellent example of this apparently contradictory phenomenon. |
| Databáze: | OpenAIRE |
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