Polymer-Based Bioorthogonal Nanocatalysts for the Treatment of Bacterial Biofilms
| Autor: | Erlei Yu, Vincent M. Rotello, Roberto Cao-Milán, Luke D. He, Rui Huang, Jessa Marie Makabenta, Xianzhi Zhang, Cheng-Hsuan Li |
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| Rok vydání: | 2020 |
| Předmět: |
inorganic chemicals
Biocompatibility Polymers Metal Nanoparticles Nanoparticle Nanotechnology Microbial Sensitivity Tests 010402 general chemistry 01 natural sciences Biochemistry Article Catalysis Colloid and Surface Chemistry Escherichia coli Transition Elements chemistry.chemical_classification Molecular Structure Chemistry Extramural Biofilm General Chemistry Polymer Nanomaterial-based catalyst Anti-Bacterial Agents 0104 chemical sciences Biofilms Bioorthogonal chemistry |
| Zdroj: | J Am Chem Soc |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.0c01758 |
| Popis: | Bioorthogonal catalysis offers a unique strategy to modulate biological processes through the in situ generation of therapeutic agents. However, the direct application of bioorthogonal transition metal catalysts (TMCs) in complex media poses numerous challenges due to issues of limited biocompatibility, poor water solubility, and catalyst deactivation in biological environments. We report here the creation of catalytic "polyzymes", comprised of self-assembled polymer nanoparticles engineered to encapsulate lipophilic TMCs. The incorporation of catalysts into these nanoparticle scaffolds creates water-soluble constructs that provide a protective environment for the catalyst. The potential therapeutic utility of these nanozymes was demonstrated through antimicrobial studies in which a cationic nanozyme was able to penetrate into biofilms and eradicate embedded bacteria through the bioorthogonal activation of a pro-antibiotic. |
| Databáze: | OpenAIRE |
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