| Autor: |
Ayelen T. Eberhardt, Melina Simoncini, Carlos Piña, Germán Galoppo, Virginia Parachú-Marco, Andrea Racca, Sofía Arce, Evangelina Viotto, Florencia Facelli, Florencia Valli, Cecilia Botto, Leonardo Scarpa, Celina Junges, Cintia Palavecino, Camila Beccaria, Diego Sklar, Graciela Mingo, Alicia Genolet, Mónica Muñoz de Toro, Hugo Aimar, Verónica Marignac, Juan Carlos Bossio, Gustavo Armando, Hugo Fernández, Pablo M. Beldomenico |
| Rok vydání: |
2022 |
| Předmět: |
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| DOI: |
10.1101/2022.05.18.22275138 |
| Popis: |
The SARS-CoV-2 Omicron variant has increased infectivity and immune escape compared with previous variants, and caused the surge of massive COVID-19 waves globally. Despite a vast majority (~90%) of the population of Santa Fe city, Argentina had been vaccinated and/or had been infected by SARS-CoV-2 when Omicron emerged, the epidemic wave that followed its arrival was by far the largest one experienced in the city. A serosurvey conducted prior to the arrival of Omicron allowed to assess the acquired humoral defences preceding the wave and to conduct a longitudinal study to provide individual-level real-world data linking antibody levels and protection against COVID-19 during the wave. A very large proportion of 1455 sampled individuals had immunological memory against COVID-19 at the arrival of Omicron (almost 90%), and about half (48.9%) had high anti-spike immunoglobulin G levels (>200 UI/ml). However, the antibody titres varied greatly among the participants, and such variability depended mainly on the vaccine platform received, on having had COVID-19 previously and on the number of days elapsed since last antigen exposure (vaccine shot or natural infection). A follow-up of 514 participants provided real-world evidence of antibody-mediated protection against COVID-19 during a period of high risk of exposure to an immune-escaping highly transmissible variant. Pre-wave antibody titres were strongly negatively associated with COVID-19 incidence and severity of symptoms during the wave. Also, receiving a vaccine shot during the follow-up period reduced the COVID-19 risk drastically (15-fold). These results highlight the importance of maintaining high defences through vaccination at times of high risk of exposure to immune-escaping variants. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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