Phosphohistone H3 outperforms Ki67 as a marker of outcome for breast cancer patients

Autor:	John F. Pearson, Zac Gerring, Helen Morrin, Bridget A. Robinson, Logan C. Walker, Gavin C. Harris
Rok vydání:	2015
Předmět:	Adult Oncology Prognostic variable medicine.medical_specialty Pathology Histology Breast Neoplasms Kaplan-Meier Estimate Pathology and Forensic Medicine Histones Breast cancer Internal medicine Biomarkers Tumor Humans Medicine Proliferation Marker Phosphorylation Aged Proportional Hazards Models Tissue microarray business.industry Hazard ratio General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Staining Ki-67 Antigen Tissue Array Analysis Female business Phosphohistone h3
Zdroj:	Histopathology. 67:538-547
ISSN:	0309-0167
DOI:	10.1111/his.12678
Popis:	The proliferation marker Ki67 has been extensively investigated as a prognostic factor in breast cancer, but has not gained widespread clinical acceptance. Phosphohistone H3 is a new immunohistochemical marker for quantifying mitoses; however, there is limited information on its prognostic value in breast cancer. In this study, we performed a head-to-head comparison of Ki67 and phosphohistone H3 to establish the marker with the greatest prognostic value.Tissue microarrays from 108 breast cancer patients were immunohistochemically stained for Ki67 and phosphohistone H3. Our results showed that phosphohistone H3 had a greater prognostic value than Ki67 in a multivariable model that adjusted for traditional prognostic variables in breast cancer. Phosphohistone H3 staining was a stronger predictor of survival at 5 years after diagnosis [hazard ratio (HR) 4.35, P10(-5) ] than Ki67 (HR 2.44, P = 0.004), and better separated the risk of death in patients aged45 years. Importantly, phosphohistone H3 consistently showed strong unequivocal staining, in contrast to the variable staining intensities associated with Ki67.Our study suggests that phosphohistone H3 staining is a stronger and more robust prognostic indicator than Ki67 staining in breast cancer patients, and has the potential for use in routine diagnostic laboratories.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9dca12936602340d7f7f23308769bec https://doi.org/10.1111/his.12678 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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