Mizoroki–Heck reaction of 1,2-disubstituted aryl alkenes: Variables of synthesis, solvent and ligand modulation of reactivity

Autor:	Pronnoy G. Bangar, Priyanka R. Jawalkar, Shana Sudhakaran, Dharmaraj J. Patil, Pallavi K. Raut, Swapnil R. Dumbre, Suresh Iyer, Neethu Tv
Rok vydání:	2020
Předmět:	010405 organic chemistry Ligand Aryl Organic Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Solvent chemistry.chemical_compound chemistry Heck reaction Reactivity (chemistry) Phosphine
Zdroj:	Synthetic Communications. 50:3796-3803
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397911.2020.1811986
Popis:	Reaction of aryl iodides with 1,2-disubstituted aryl alkenes in the presence of TBABr/TBACl gave high yields of the Mizoroki–Heck product. Phosphine ligands were used for the modulation of reactivity and stereoselectivity, for the reaction of 4-iodoanisole with cinnamaldehyde. tert-Bu3P.HBF4 gave the highest E:Z ratio of 1:0.08. The use of PEG-200 and PEG-400 as solvent could activate the reaction of aryl iodides with various 1,2-disubstituetd aryl alkenes.
Databáze:	OpenAIRE
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