Daphnane Diterpene Esters with Anti-proliferative Activities against Human Lung Cancer Cells from Daphne genkwa
Autor: | Joo Won Nam, Ji-Young Hong, Sang Kook Lee, Eun Kyoung Seo |
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Rok vydání: | 2010 |
Předmět: |
Daphne genkwa
Lung Neoplasms Stereochemistry Flowers Cell Line chemistry.chemical_compound Cell Line Tumor Drug Discovery Humans Cytotoxicity Lung Cell Proliferation Molecular Structure biology Terpenes Epithelial Cells General Chemistry General Medicine respiratory system biology.organism_classification Antineoplastic Agents Phytogenic In vitro respiratory tract diseases chemistry Heteronuclear molecule Cell culture Thymelaeaceae Daphne Diterpenes Diterpene Two-dimensional nuclear magnetic resonance spectroscopy |
Zdroj: | Chemical and Pharmaceutical Bulletin. 58:234-237 |
ISSN: | 1347-5223 0009-2363 |
Popis: | Two new daphnane-type diterpene esters, yuanhuahine (1) and yuanhualine (2), were isolated from the flowers of Daphne genkwa (Thymelaeaceae) along with three known diterpene esters, yuanhuacine (3), yuanhuadine (4), and yuanhuagine (5). Their structures were determined by a combination of 1D and 2D NMR experiments, including correlation spectroscopy (COSY), heteronuclear multiple quantum correlation (HMQC), heteronuclear multiple bond correlation (HMBC), and rotating frame Overhauser enhancement spectroscopy (ROESY) sequences, and mass spectrometry. All the isolated compounds were tested against A549 human lung cancer cells and MRC-5 human normal lung epithelial cells. Compounds 1-5 exhibited potent anti-proliferative effects against A549 lung cancer cells with IC(50) values of 12-53 nM, whereas these compounds were relatively non-cytotoxic against MRC-5 normal lung epithelial cells. |
Databáze: | OpenAIRE |
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