Ocular abnormalities in patients with beta thalassemia on transfusion and chelation therapy: Our experience
| Autor: | Jitendra Jethani, Kenshuk Marwah, Shashank M. Patel, Bela Shah, Nikul |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Eye Diseases Pyridones Visual Acuity Retinal Pigment Epithelium Deferoxamine Iron Chelating Agents Cataract Young Adult Text mining lcsh:Ophthalmology Internal medicine medicine Humans In patient Blood Transfusion Deferiprone Chelation therapy Letters to Editor Child business.industry beta-Thalassemia Beta thalassemia Infant medicine.disease Ophthalmology lcsh:RE1-994 Child Preschool Female business |
| Zdroj: | Indian Journal of Ophthalmology Indian Journal of Ophthalmology, Vol 58, Iss 5, Pp 451-452 (2010) |
| ISSN: | 1998-3689 0301-4738 |
| Popis: | To study the ocular manifestations in multiple transfused beta-thalassemia major patients and assess the ocular side-effects of iron chelating agents.In this prospective observational study, 45 multiple transfused beta-thalassemia major children between six months and 21 years of age were enrolled and assigned groups according to the treatment regimens suggested. Group A received only blood transfusions, Group B blood transfusions with subcutaneous desferrioxamine, Group C blood transfusions with desferrioxamine and oral deferriprone and Group D blood transfusions with deferriprone. Ocular status at the time of enrolment was documented. Subjects were observed quarterly for one year for changes in ocular status arising due to the disease process and due to iron chelation therapy. Children with hemoglobinopathies other than beta-thalassemia major, congenital ocular anomalies and anemia due to other causes were excluded.Ocular involvement was observed in 58% of patients. Lenticular opacities were the most common ocular finding (44%), followed by decreased visual acuity (33%). An increased occurrence of ocular changes was observed with increase of serum ferritin and serum iron levels as well as with higher number of blood transfusions received. Desferrioxamine seemed to have a protective influence on retinal pigment epithelium (RPE) mottling. Occurrence of lenticular opacities and RPE degeneration correlated positively with use of desferrioxamine and deferriprone respectively. Follow-up of patients for one year did not reveal any change in ocular status.Regular ocular examinations can aid in preventing, delaying or ameliorating the ocular complications of thalassemia. |
| Databáze: | OpenAIRE |
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