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The purpose of the study was to determine potential availability of anti-retrovirus therapy and to justify proposals for selecting and prescribing rational combining of anti-retrovirus medications for HIV treatment. The objects of the study were anti-retrovirus medications authorized in the Russian Federation, information on current national and international approaches and recommendations concerning management of HIV-infected patient and application of anti-retrovirus therapy, including criteria of selecting medications and their combinations. The mathematical approach was applied to calculate the number of potential combinations of anti-retrovirus medications that can be applied to objects in certain conditions. The systemic approach was implemented including content analysis, methods of comparative and one-off analysis, generalization and grouping of information from regulatory documents on anti-retrovirus therapy and official materials on anti-retrovirus medications to develop algorithm of rational selection of anti-retrovirus treatment. Based on the results of the study, large number of potential combinations of anti-retrovirus medications were established to select the proper combination for treatment of HIV infection. The approach included organizational steps, evaluation criteria and algorithm of selecting rational combination of anti-retrovirus medications. The practical implementation of developed proposals can contribute to development of system of rational use of medications at the level of medical organization and to improve medication support of patients with HIV infection. |
