Neonatal jaundice, aflatoxins and naphthols: report of a study in Ibadan, Nigeria
| Autor: | R. G. Hendrickse, Olugbemiro Sodeinde, M. C. K. Chan, J. B. Familusi, S. M. Maxwell |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Aflatoxin
medicine.medical_specialty Pediatrics 030231 tropical medicine Population Nigeria Gestational Age Naphthols 03 medical and health sciences 0302 clinical medicine Aflatoxins Risk Factors 030225 pediatrics Odds Ratio Prevalence medicine Humans Risk factor education Retrospective Studies education.field_of_study Obstetrics business.industry Glucosephosphates Infant Newborn Gestational age Bilirubin Retrospective cohort study Odds ratio Jaundice Confidence interval Jaundice Neonatal Blood Group Incompatibility Pediatrics Perinatology and Child Health Regression Analysis Female medicine.symptom business |
| Zdroj: | Annals of Tropical Paediatrics. 15:107-113 |
| ISSN: | 1465-3281 0272-4936 |
| Popis: | This study set out to investigate the prevalence of naphthols and aflatoxins in the sera of babies with neonatal jaundice and their mothers in order to determine whether they contribute to the occurrence of unexplained neonatal jaundice in Ibadan. Blood was obtained from 327 jaundiced neonates and 80 of their mothers, and 60 non-jaundiced controls and seven of their mothers admitted to hospital between April 1989 and April 1991. Blood group, bilirubin concentration, erythrocyte G6PD status, aflatoxin and naphthol concentrations in blood were measured. Altogether, 30.9% of the jaundiced neonates were G6PD-deficient, compared with 13.3% of controls (chi 2 = 6.88; p = 0.009). Aflatoxins were detected in 27.4% of jaundiced neonates, 17% of their mothers, 16.6% of controls and 14.4% of control mothers. Naphthols were detected in 7.2% of jaundiced babies, 6.3% of their mothers, 6.25% of control babies and 14.4% of their mothers. Analysis of the data revealed that either G6PD deficiency or the presence of any serum aflatoxin is a risk factor for neonatal jaundice; odds ratio were 2.97 (95%) confidence intervals (CI): 1.31-6.74) and 2.68 (CI: 1.18-6.10), respectively. This study demonstrates that G6PD deficiency and/or the presence of serum aflatoxins are risk factors for neonatal jaundice in Nigeria. Aflatoxins are an additional risk factor not previously reported. |
| Databáze: | OpenAIRE |
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