Autoradiography-based, three-dimensional calculation of dose rate for murine, human-tumor xenografts
| Autor: | Farley E. Yang, Richard L. Wahl, Cheuk S. Kwok, James C. Sisson, Kenneth F. Koral, Raya S. Brown |
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| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
Transplantation Heterologous Mice Nude Iodine Radioisotopes Mice Neuroblastoma Nuclear magnetic resonance medicine Distribution (pharmacology) Dosimetry Animals Humans Radiology Nuclear Medicine and imaging Ovarian Neoplasms Mice Inbred BALB C Dose-Response Relationship Drug Fourier Analysis Chemistry business.industry Radiotherapy Planning Computer-Assisted Radiotherapy Dosage medicine.disease Human tumor Molecular Medicine Autoradiography Female Nuclear medicine business Dose rate Neoplasm Transplantation |
| Zdroj: | Nuclear medicine and biology. 20(8) |
| ISSN: | 0969-8051 |
| Popis: | A Fast Fourier Transform method for calculating the three-dimensional dose rate distribution for murine, human-tumor xenografts is outlined. The required input includes evenly-spaced activity slices which span the tumor. Numerical values in these slices are determined by quantitative 125I autoradiography. For the absorbed dose-rate calculation, we assume the activity from both 131I- and 90Y-labeled radiopharmaceuticals would be distributed as is measured with the 125I label. Two example cases are presented: an ovarian-carcinoma xenograft with an IgG 2ak monoclonal antibody and a neuroblastoma xenograft with meta-iodobenzylguanidine (MIBG). Considering all the volume elements in a tumor, we show, by comparison of histograms and also relative standard deviations, that the measured 125I activity and the calculated 131I dose-rate distributions, are similarly non-uniform and that they are more non-uniform than the calculated 90Y dose-rate distribution. However, the maximum-to-minimum ratio, another measure of non-uniformity, decreases by roughly an order of magnitude from one distribution to the next in the order given above. |
| Databáze: | OpenAIRE |
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