Tolerance to Effects of High-Dose Oral Δ9-Tetrahydrocannabinol and Plasma Cannabinoid Concentrations in Male Daily Cannabis Smokers
| Autor: | Catherine Ortemann-Renon, Deanna L. Kelly, Robert P. McMahon, David M. Schwope, David A. Gorelick, Marilyn A. Huestis, Eugene W. Schwilke, Fang Liu, Denis Bonnet, William D. Darwin, Robert S. Goodwin |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Chromatography Gas Adolescent Health Toxicology and Mutagenesis medicine.medical_treatment Physiology Marijuana Smoking Pharmacology Toxicology Mass Spectrometry Analytical Chemistry Young Adult Receptor Cannabinoid CB1 Drug tolerance Heart rate mental disorders medicine Environmental Chemistry Humans Dronabinol Morning Cannabis Chemical Health and Safety biology Dose-Response Relationship Drug Chemistry Cannabinoids organic chemicals Articles Drug Tolerance Middle Aged biology.organism_classification Dose–response relationship Blood pressure Cannabinoid |
| Popis: | Oral cannabinoids are taken for medicinal or recreational purposes, yet little is known about tolerance to their effects after high-dose extended exposure. The development of tolerance to effects of around-the-clock oral synthetic Δ9-tetrahydrocannabinol (THC) (20 mg every 3.5-6 h) was evaluated in 13 healthy male daily cannabis smokers residing on a secure research unit: 40 mg on Day 1; 100 mg on Days 2-4; 120 mg on Days 5-6. Systolic and diastolic blood pressure (BP), heart rate, and symptoms of subjective intoxication (100 mm visual-analogue scales, VAS) were assessed the morning of Day 1 (before any oral THC), and on Days 2, 4 and 6, every 30 min for 3 h after the first morning THC dose. Morning subjective intoxication ratings increased from Days 1 to 2, and then declined on Days 4 and 6. The morning THC dose increased intoxication ratings on Day 2, but had less effect on Days 4 and 6, a pattern consistent with tolerance. THC lowered BP and increased heart rate over the six days. Plasma THC and 11-OH-THC concentrations increased significantly over the first five days of dosing. Six days of around-the-clock, oral THC produced tolerance to subjective intoxication, but not to cardiovascular effects. |
| Databáze: | OpenAIRE |
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