Preparation and Evaluation of Nanostructured Lipid Carrier for Topical Delivery of Velutin: Synthetic Tyrosinase Inhibitor
| Autor: | Ji-Hun Sung, Se Hyeop Cheon, Hee-Cheol Kim, Ji-Won Jang, Kooyeon Lee, Dong-Jin Jang, Jeong Gi Lee, Se-Hee Choi, Sang Yeob Park, Sung Tae Kim, Se Hoon Jeong |
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| Rok vydání: | 2021 |
| Předmět: |
Drug Carriers
Cetyl palmitate Materials science Chromatography Calorimetry Differential Scanning Monophenol Monooxygenase Scanning electron microscope Tyrosinase Dispersity Biomedical Engineering Nanoparticle Bioengineering General Chemistry Velutin Flavones Condensed Matter Physics Lipids Tyrosinase inhibitor Nanostructures chemistry.chemical_compound chemistry Dynamic light scattering Nanoparticles General Materials Science Particle Size |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 21:4093-4097 |
| ISSN: | 1533-4880 |
| Popis: | The purpose of this study is to produce nanostructured lipid carrier (NLC) that can solubilize poorly water-soluble velutin and verify an improved tyrosinase synthesis inhibition. A solubility test for velutin was conducted. Cetyl palmitate and caprylic/capric triglyceride were selected as solubilizer. The lipid matrix was produced using the ultrasound dispersion method. The morphology and size distribution of the produced NLC was analyzed through scanning electron microscopy (SEM) and dynamic light scattering (DLS), and the release and tyrosinase inhibition of velutin was evaluated through the Franz diffusion cell method and tyrosinase inhibition assay. Lipid matrix nanoparticles showed an average size of approximately 250 nm and polydispersity of 0.2, and it was confirmed that the velutin incorporated within nanoparticles sustained release at a constant rate over 36 hours. Due to extremely low aqueous solubility, the tyrosinase synthesis inhibition of velutin suspension was 0%, and the value of velutin incorporated within the NLC formulation was greatly improved 56.5% (40 μg/mL). As a result, it was verified that lipid-based NLC nanoparticles are an efficient formulation for the topical delivery of poorly water-soluble flavonoids such as velutin. |
| Databáze: | OpenAIRE |
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