Effect of flavan-3-ols on the adhesion of potential probiotic lactobacilli to intestinal cells
| Autor: | Teresa Requena, Tomás García-Cayuela, Carmen Peláez, M. Carmen Martínez-Cuesta, Irene Bustos, Blanca Hernández-Ledesma |
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| Přispěvatelé: | Comunidad de Madrid, Ministerio de Ciencia e Innovación (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo |
| Rok vydání: | 2012 |
| Předmět: |
Lactobacillus casei
Epigallocatechin gallate Flavan-3-ols Bacterial Adhesion Microbiology law.invention chemistry.chemical_compound Probiotic Lactobacillus acidophilus law Cytotoxic T cell Humans Flavonoids biology Probiotics food and beverages Polyphenols General Chemistry Adhesion biology.organism_classification Microecology Intestines Lactobacillus Biochemistry chemistry Lactobacilli Caco-2 Cells General Agricultural and Biological Sciences Lactobacillus plantarum |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1520-5118 |
| Popis: | The effect of dietary flavan-3-ols on the adhesion of potential probiotic lactobacilli strains to intestinal cells was unraveled. The inhibitory activity of these compounds on intestinal cells was highlighted. The cytotoxic effect was shown to depend on both the compound¿s chemical structure (galloylation and polymerization) and degree of differentiation of intestinal cells. The effect of flavan-3-ols on bacteria adhesion differed greatly between compounds, strains, and intestinal cells. All flavan-3-ols inhibited significantly Lactobacillus acidophilus LA-5 and Lactobacillus plantarum IFPL379 adhesion except epigallocatechin gallate, which enhanced L. acidophilus LA-5 adhesion to Caco-2. Procyanidins B1 and B2 increased remarkably the adhesion of Lactobacillus casei LC115 to HT-29 cells, whereas epigallocatechin increased L. casei LC115 adhesion to Caco-2. These data showed the potential of flavan-3-ols to alter gut microecology by modifying adhesion of lactobacilli strains to intestinal cells. This work has been funded by the Spanish Ministry for Science and Innovation (AGL2009-13361-C02-02 and Consolider Ingenio 2010 FUN-C-FOOD CSD2007-00063), the Comunidad Autónoma de Madrid (ALIBIRD P2009/AGR-1469), and CYTED (IBEROFUN 110AC0386). B.H.-L. thanks the Spanish National Research Council (CSIC) for her postdoctoral research JAE-Doc contract. |
| Databáze: | OpenAIRE |
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