Vancomycin blocks autophagy and induces interleukin-1β release in macrophages
| Autor: | Dong-Hou Kim, Seung-Yong Yoon, Kyoung-Hye Kong, Young Eun Ha, Mi-Hyang Cho, Youngsup Song |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Lipopolysaccharides
medicine.drug_class Interleukin-1beta Antibiotics Inflammation Biology Cell Line Sepsis Mice Vancomycin Drug Discovery Autophagy medicine Animals Humans Pharmacology Macrophages biochemical phenomena metabolism and nutrition medicine.disease Systemic Inflammatory Response Syndrome Anti-Bacterial Agents Systemic inflammatory response syndrome Cell culture Immunology medicine.symptom medicine.drug Immunoresponse |
| Zdroj: | The Journal of Antibiotics. 68:76-80 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.1038/ja.2014.112 |
| Popis: | Systemic inflammatory response syndrome (SIRS) is a serious condition that can cause organ failure as an exaggerated immunoresponse to the infection or other causes. Recently, autophagy was reported as a key process that regulates inflammatory responses in macrophages. Vancomycin is one of the most commonly prescribed antibiotics for sepsis treatment or following surgery. However, there are no studies on how vancomycin affects autophagy or inflammation. Here, we treated macrophage cell lines with vancomycin and lipopolysaccharides and found that vancomycin blocks autophagy and increases inflammatory responses. This finding suggests that vancomycin should be more cautiously administered in order to prevent unwanted SIRS during sepsis. |
| Databáze: | OpenAIRE |
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