The values of urinary NTx in postmenopausal women undergoing HRT; the role of additional alendronate therapy
| Autor: | Banu Onvural, Hüray İşlekel, Emel Altekin, Sabahattin Altunyurt, Uğur Saygili, Cemal Posaci, Ata Önvural |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Norethisterone medicine.drug_class medicine.medical_treatment Osteoporosis Administration Oral Administration Cutaneous Collagen Type I General Biochemistry Genetics and Molecular Biology N-terminal telopeptide Bone Density Internal medicine medicine Humans Prospective Studies Osteoporosis Postmenopausal Alendronate Estradiol business.industry Alendronic acid Estrogen Replacement Therapy Obstetrics and Gynecology Hormone replacement therapy (menopause) Middle Aged medicine.disease Norethisterone acetate Postmenopause Menopause Norethindrone Acetate Endocrinology Estrogen Female Collagen Norethindrone Peptides business human activities medicine.drug |
| Zdroj: | Maturitas. 42:281-286 |
| ISSN: | 0378-5122 |
| DOI: | 10.1016/s0378-5122(02)00156-1 |
| Popis: | Objective: To determine the changes in levels of urinary NTx at the end of the 6th month of oral and transdermal hormone replacement therapy (HRT) and the effects of additional alendronate therapy for osteoporotic women. Method: Of 66 postmenopausal women 23 were treated with oral estradiol + norethisterone acetate (E + P), and 22 were treated with transdermal estradiol+norethisterone acetate. The third group consisted of 21 women with osteoporosis (bone mineral density < 100 mg/cm(3)) and treated with oral E+P plus alendronate 10 mg/day. Result: Significant decreases of urinary NTx levels were seen after HRT in all study groups (P < 0.05). But the decline of NTx levels was not different between the oral and transdermal HRT groups (P > 0.05). There was no additional decrease in the levels of NTx with alendronate therapy (P > 0.05) but NTx excretion diminished more in patients with high baseline levels. Conclusion: The decline of NTx at the end of the 6th month of HRT reflects the decrease of bone resorption and it is not related to the route of administration. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect