Pulse pressure amplification during exercise is significantly reduced with age and hypercholesterolemia
| Autor: | Zahid Dhakam, James E. Sharman, Carmel M. McEniery, Jeff S. Coombes, John R. Cockcroft, Ian B. Wilkinson |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Systole Physiology Hypercholesterolemia Hemodynamics Blood Pressure Physical exercise Risk Assessment Diastole Heart Rate Internal medicine Heart rate Internal Medicine medicine Humans Exercise physiology Pulse Exercise Aged business.industry Middle Aged medicine.disease Lipids Pulse pressure Blood pressure Endocrinology Cardiovascular Diseases Radial Artery Exercise Test Arterial stiffness Cardiology and Cardiovascular Medicine business |
| Zdroj: | ResearcherID |
| ISSN: | 0263-6352 |
| Popis: | Objectives Exercise brachial blood pressure (BP) is predictive of cardiovascular events. As a result of the amplification of pulse pressure, central BP (a stronger cardiovascular risk factor) differs significantly from peripheral measures. Pulse pressure amplification is reduced with increasing age and hypercholesterolemia at rest, but the effect of exercise on central pressure in these populations is unknown. This study aimed to assess the central and peripheral BP response to exercise with aging and hypercholesterolernia. Methods Twenty healthy younger (aged 29 +/- 5 years; mean +/- SD), 20 healthy older (aged 57 +/- 5 years) and 12 matched older (aged 59 +/- 7 years) men with hypercholesterolemia exercised (bicycle ergometer) at 60% of their predicted maximal heart rate. Central BP and augmentation index (AIx), a marker of systemic arterial stiffness, were obtained non-invasively using pulse wave analysis. Pulse pressure amplification was defined as the ratio of peripheral to central pulse pressure. Results The resting haemodynamics of the older men were not significantly different from those with hypercholesterolemia. During exercise, amplification was significantly lower (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|