A novel technique to determine an 'apparent k(e0)' value for use with the Marsh pharmacokinetic model for propofol
| Autor: | F. H. M. Engbers, A. J. Thomson, A. F. Nimmo, J. B. Glen |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Novel technique business.industry Sedation Middle Aged Target concentration Models Biological Young Adult Anesthesiology and Pain Medicine Pharmacokinetics Visual reaction time Anesthesia Pharmacodynamics Humans Medicine Female medicine.symptom business Propofol Value (mathematics) Anesthetics Intravenous Aged medicine.drug |
| Zdroj: | Anaesthesia, 69(5), 420-428 |
| Popis: | Summary Debate continues over the most appropriate blood–brain equilibration rate constant (ke0) for use with the Marsh pharmacokinetic model for propofol. We aimed to define the optimal ke0 value. Sixty-four patients were sedated with incremental increases in effect-site target concentration of propofol while using six different ke0 values within the range 0.2–1.2 min−1. Depth of sedation was assessed by measuring visual reaction time. A median ‘apparent ke0’ value of 0.61 min−1 (95% CI 0.37–0.78 min–1) led to the greatest probability of achieving a stable clinical effect when the effect-site target was fixed at the effect-site concentration displayed by the target-controlled infusion system, at the time when a desired depth of sedation had been reached. By utilising a clinically relevant endpoint to derive this value, inter-individual pharmacokinetic and pharmacodynamic variability may be accounted for. |
| Databáze: | OpenAIRE |
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