Efficacy and Safety of Topical Lysostaphin Treatment of Persistent Nasal Carriage of Staphylococcus aureus
| Autor: | Richard Selden, Jacques R. Caldwell, Nedo F. Nora, Kenneth E. Quickel, William Schaffner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1971 |
| Předmět: |
Adult
Time Factors medicine.medical_treatment Staphylococcus Population Nose medicine.disease_cause Staphylococcal infections General Biochemistry Genetics and Molecular Biology Diagnosis Differential Ointments Placebos Bacitracin Intellectual Disability medicine Humans Polymyxins General Pharmacology Toxicology and Pharmaceutics education Child Bacteriophage Typing Skin Tests Aerosols education.field_of_study Clinical Trials as Topic General Immunology and Microbiology Lysostaphin business.industry Neomycin General Medicine Hemagglutination Inhibition Tests Staphylococcal Infections medicine.disease Anti-Bacterial Agents Carriage medicine.anatomical_structure Nasal spray Staphylococcus aureus Evaluation Studies as Topic Immunology Carrier State Clinical Microbiology Virology and Immunology business |
| Popis: | The efficacy of lysostaphin nasal spray and Neosporin ointment (Burroughs Wellcome & Co.) in altering nasal carriage of Staphylococcus aureus was studied with persistent carriers in an institution for mentally retarded children and adults. Treatment for 5 days with either agent significantly reduced carriage rates. This effect persisted through the 5th day after therapy with lysostaphin but not with Neosporin. By the 11th day after therapy, carriage rates in the treatment and control groups were not significantly different. Except for a single immediate wheal and flair skin test reaction, no other evidence of adverse reactions to topical lysostaphin was detected. No consistent changes in hemagglutination-inhibition titers to lysostaphin were observed after therapy. Lysostaphin appears to be slightly more effective than conventional topical antimicrobial therapy in reducing nasal carriage of staphylococci in this rigorously defined population of persistent carriers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|