Neurofilament light chain in patients with a concussion or head impacts: a systematic review and meta-analysis
| Autor: | Fivos Petridis, Jack McKenna, Dimitrios Kazis, Eleni Karantali, Symela Chatzikonstantinou, Ioannis Mavroudis |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Sports medicine Traumatic brain injury Neurofilament light Intermediate Filaments Critical Care and Intensive Care Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine Brain Injuries Traumatic Concussion Humans Medicine Orthopedics and Sports Medicine In patient Brain Concussion 030222 orthopedics business.industry 030208 emergency & critical care medicine medicine.disease Military Personnel Meta-analysis Potential biomarkers Emergency Medicine Biomarker (medicine) Surgery business Biomarkers |
| Zdroj: | European Journal of Trauma and Emergency Surgery. 48:1555-1567 |
| ISSN: | 1863-9941 1863-9933 |
| DOI: | 10.1007/s00068-021-01693-1 |
| Popis: | Traumatic brain injury is one of the leading causes of disability worldwide. Mild traumatic brain injury (TBI) is the most common and benign form of TBI, usually referred to by the medical term “concussion”. The purpose of our systematic review and meta-analysis was to explore the role of serum and CSF neurofilament light chain (NfL) as a potential biomarker in concussion. We systematically searched PubMed, Web of Science, and Cochrane databases using specific keywords. As the primary outcome, we assessed CSF or serum NfL levels in patients with concussion and head impacts versus controls. The role of NfL in patients with concussion and head impacts compared to healthy controls was also assessed, as well as in sports-related and military-related conditions. From the initial 617 identified studies, we included 24 studies in our qualitative analysis and 14 studies in our meta-analysis. We found a statistically significant increase of serum NfL in patients suffering from a concussion or head impacts compared to controls (p = 0.0023), highlighting its potential role as a biomarker. From our sub-group analyses, sports-related concussion and mild TBI were mostly correlated with increased serum NfL values. Compared to controls, sports-related concussion was significantly associated with higher NfL levels (p = 0.0015), while no association was noted in patients suffering from head impacts or military-related TBI. Serum NfL levels are higher in all patients suffering from concussion compared to healthy controls. The sports-related concussion was specifically associated with higher levels of NfL. Further studies exploring the use of NfL as a diagnostic and prognostic biomarker in mild TBI and head impacts are needed. |
| Databáze: | OpenAIRE |
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