Immunohistochemistry of gliosarcoma with liposarcomatous differentiation
| Autor: | Toshimitsu Suzuki, Kasuya Yasumichi, Takeaki Fukuda |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Pathology medicine.medical_specialty Necrosis Gliosarcoma Brain tumor Liposarcoma Retinoblastoma Protein S100 protein Pathology and Forensic Medicine Fatal Outcome Glial Fibrillary Acidic Protein Biomarkers Tumor medicine Humans Aged biology Glial fibrillary acidic protein Brain Neoplasms business.industry S100 Proteins Retinoblastoma protein General Medicine medicine.disease Immunohistochemistry Magnetic Resonance Imaging biology.protein medicine.symptom business |
| Zdroj: | Pathology International. 58:396-401 |
| ISSN: | 1440-1827 1320-5463 |
| DOI: | 10.1111/j.1440-1827.2008.02242.x |
| Popis: | A case of gliosarcoma composed of glioblastoma and liposarcoma is presented. A 70-year-old Japanese man was admitted to hospital because of dysarthria and aphasia. Magnetic resonance imaging indicated a brain tumor located in the temporal-parietal area of the left hemisphere. He rejected any therapy and died of respiratory failure. At autopsy the tumor was well-demarcated with firm consistency and myxoid appearance, accompanied by necrosis and hemorrhage. Microscopically the tumor consisted of both glial and sarcomatous components, compatible with a gliosarcoma. Lipoblast-like tumor cells were identified in the sarcomatous area. Glial component was observed in the periphery and was diffusely positive for CD56 and S100 protein and focally for glial fibrillary acidic protein. Only a small number of tumor cells in the sarcomatous area expressed neurogenic markers. Lipoblast-like tumor cells were positive for S100 protein but negative for any other neurogenic markers. A significant number of tumor cells were positive for retinoblastoma protein (pRB) in the glial area, whereas only a few of them were positive in the sarcomatous area, indicating alteration of pRB in sarcomatous component. The present tumor is a rare gliosarcoma with liposarcomatous differentiation; alteration of pRB may play a role in sarcomatous transformation of glial component. |
| Databáze: | OpenAIRE |
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