Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia
| Autor: | Jyoti N. Sengupta, Adrian Miranda, Peter G. McLean, Shachar Peles |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Colon medicine.drug_class medicine.medical_treatment Injections Intramuscular 5-HT3 receptor Absorption Rats Sprague-Dawley chemistry.chemical_compound 5-HT3 Receptor Antagonist Internal medicine medicine Animals Serotonin 5-HT3 Receptor Antagonists Neurotransmitter Saline Injections Spinal Pain Measurement biology Electromyography business.industry Rectum Receptor antagonist Rats Viscera Anesthesiology and Pain Medicine Endocrinology Neurology chemistry Hyperalgesia Alosetron biology.protein Serotonin Antagonists Neurology (clinical) Serotonin medicine.symptom Gastrointestinal Motility business Carbolines Dilatation Pathologic medicine.drug |
| Zdroj: | Pain. 126:54-63 |
| ISSN: | 0304-3959 |
| DOI: | 10.1016/j.pain.2006.06.014 |
| Popis: | Conflicting results exist regarding the role of 5-HT3 receptors in somatic and visceral nociceptive processing. We aimed to investigate the effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Two injections (100 microl) of either pH 4.0 or 7.2 saline were given unilaterally in the gastrocnemius (GN) muscle. In all groups, the paw withdrawal thresholds (PWT) to von Frey filaments and the visceromotor responses (VMR) to colorectal distension (CRD) were recorded before the saline injections and 72 h, and 1 week after the second injection. Intrathecal (i.t.) (25 nmol) or intravenous (i.v.) (100 microg/kg/day) alosetron was given daily following the second injection and compared to either i.v. or i.t. saline (vehicle). There was a significant decrease in the mean PWT bilaterally in all groups following pH 4.0 injections (p |
| Databáze: | OpenAIRE |
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