Specific long non-coding RNAs response to occupational PAHs exposure in coke oven workers
| Autor: | Zhengbao Zhang, Yongmei Xiao, Xiao-Wen Zeng, Daochuan Li, Zhini He, Xiao Zhang, Shan Wang, Liping Chen, Chen Gao, Xiao Li, Qing Bai, Qing Wang, Guang-Hui Dong, Xinhua Xiao, Jie Li, Fangping Wang, Yan Yan, Yuxin Zheng, Wen Chen |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Coke oven DNA damage Health Toxicology and Mutagenesis H2K27me3 histone 3 lysine 27 trimethylation MALAT Biology DNA damage response Toxicology Article Andrology 03 medical and health sciences HOTAIR PAHs polycyclic aromatic hydrocarbons lcsh:RA1190-1270 mental disorders HOTAIR HOX transcript antisense RNA Peripheral blood lymphocytes lcsh:Toxicology. Poisons MALAT1 metastasis-associated lung adenocarcinoma transcript 1 MALAT1 lncRNAs long non-coding RNAs TUG1 taurine up-regulated 1 PBLCs peripheral blood lymphocytes Polycyclic aromatic hydrocarbons Long non-coding RNA Peripheral blood 1-OHP 1-hydroxypyrene 030104 developmental biology Histone 1-hydroxypyrene (PubChem CID: 21387) Cancer research biology.protein GAS5 growth arrest-specific 5 GAS5 |
| Zdroj: | Toxicology Reports, Vol 3, Iss, Pp 160-166 (2016) Scipedia Open Access Scipedia SL Toxicology Reports |
| ISSN: | 2214-7500 |
| DOI: | 10.1016/j.toxrep.2015.12.011 |
| Popis: | Highlights • HOTAIR and MALAT1 were upregulated in PBLCs of PAHs-exposed workers. • HOTAIR and MALAT1 expression was positively associated with the degree of DNA damage induced by PAHs. • H3K27me3 modification was positively correlated with the degree of genetic damage and the increase of HOTAIR expression. To explore whether the alteration of lncRNA expression is correlated with polycyclic aromatic hydrocarbons (PAHs) exposure and DNA damage, we examined PAHs external and internal exposure, DNA damage and lncRNAs (HOTAIR, MALAT1, TUG1 and GAS5) expression in peripheral blood lymphocytes (PBLCs) of 150 male coke oven workers and 60 non-PAHs exposure workers. We found the expression of HOTAIR, MALAT1, and TUG1 were enhanced in PBLCs of coke oven workers and positively correlated with the levels of external PAHs exposure (adjusted Ptrend |
| Databáze: | OpenAIRE |
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