Phyloproteomics: What Phylogenetic Analysis Reveals about Serum Proteomics

Autor:	Hakima Amri, Mones Abu-Asab, Mohamed Chaouchi
Rok vydání:	2006
Předmět:	Proteomics Serum proteomics Parsing Phylogenetic tree Blood Proteins General Chemistry Computational biology Biology Bioinformatics computer.software_genre Biochemistry Article Phylogenetics Neoplasms Humans computer Algorithms Phylogeny
Zdroj:	Journal of Proteome Research. 5:2236-2240
ISSN:	1535-3907 1535-3893
Popis:	Phyloproteomics is a novel analytical tool that solves the issue of comparability between proteomic analyses, utilizes a total spectrum-parsing algorithm, and produces biologically meaningful classification of specimens. Phyloproteomics employs two algorithms: a new parsing algorithm (UNIPAL) and a phylogenetic algorithm (MIX). By outgroup comparison, the parsing algorithm identifies novel or vanished MS peaks and peaks signifying up or down regulated proteins and scores them as derived or ancestral. The phylogenetic algorithm uses the latter scores to produce a biologically meaningful classification of the specimens.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cb70cc22f492c6bb382619d6d4cd58 https://doi.org/10.1021/pr0504485 Zobrazit plný text záznamu