Influence of hyperpnea on airway surface fluid volume and osmolarity in normal humans
| Autor: | L. J. Brianas, Rana Hejal, Albert Coreno, Chakradhar Kotaru, E. R. McFadden, J. H. Finigan, Mary Skowronski |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Physiology Hyperpnea Respiratory physiology Normal people Physiology (medical) Bronchoscopy medicine Homeostasis Humans Respiratory system Osmotic concentration Chemistry Osmolar Concentration Reproducibility of Results Humidity medicine.disease Water Loss Insensible Body Fluids Cold Temperature Trachea medicine.anatomical_structure Regional Blood Flow Anesthesia Respiratory Mechanics Respiratory Physiological Phenomena Female Airway Fluid volume Respiratory tract |
| Zdroj: | Journal of Applied Physiology. 93:154-160 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00830.2001 |
| Popis: | To determine the effect of hyperpnea on the characteristics of periciliary liquid, we collected airway surface fluid (ASF) and measured its osmolarity in 11 normal people while they breathed dry, frigid air (-17 +/- 1.2 degrees C) at minute ventilations (VE) of 10, 40, and 80 l/min through a heat exchanger. The ASF was collected at the fifth tracheal ring by absorption onto filter paper pledgets inserted via fiber-optic bronchoscopy. Hyperpnea had no influence on the amount of ASF recovered (ASF volume at a VE of 10 l/min = 12.0 +/- 2.0 microl; at 80 l/min = 8.8 +/- 1.5 microl; P = 0.28) or its osmolarity (at a VE of 10, 40, and 80 l/min = 326 +/- 15, 323 +/- 11, and 337 +/- 12 mosM, respectively; P = 0.65). These findings demonstrate that the tracheal mucosa of normal subjects does not dessicate during hyperpnea and that hypertonicity of the periciliary fluid does not develop even at high levels of ventilation. |
| Databáze: | OpenAIRE |
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