Do ACE and CKMM gene variations have potent effects on physical performance in inactive male adolescents?
| Autor: | Mehri Ghahramani, Amir Monfaredan, Amir Hamzeh Safabakhsh, Farzad Zehsaz, Narmin Keynezhad, Negin Farhangi |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Multi-stage fitness test medicine.medical_specialty Adolescent Genotype Creatine Kinase Mitochondrial Form Single-nucleotide polymorphism Athletic Performance Peptidyl-Dipeptidase A 03 medical and health sciences 0302 clinical medicine Gene Frequency Internal medicine Genetics Chi-square test Humans Medicine Child Exercise Molecular Biology Allele frequency Gene Polymorphism Genetic business.industry Genetic Variation General Medicine Physical Functional Performance Heritability Oxygen Phenotype 030104 developmental biology Physical performance 030220 oncology & carcinogenesis Physical Endurance business |
| Zdroj: | Molecular Biology Reports. 46:1835-1843 |
| ISSN: | 1573-4978 0301-4851 |
| Popis: | We studied to ascertain whether the ACE and/or CKMM genotypes independently influence the baseline level of some sport performances in 613 inactive male adolescents (mean ± SD age: 13.24 ± 0.28 years). All DNA samples were extracted and genotyped for ACE I/D and CKMM A/G polymorphisms using a PCR based procedure. One-way analysis of covariance was used to examine the discrepancies in the research phenotypes among various ACE and CKMM polymorphisms. The comparisons of genotype and allele frequencies between adolescents with the best and the worst performances were calculated and analyzed by the Chi square test. All procedures were approved by Medical University Ethics Committee. Written informed consent signed and approved by all subject`s parents were obtained. We observed the effect of the ACE and CKMM polymorphisms on VO2max (P = 0.001 & P = 0.001 respectively). ACE and CKMM genotypes differed between groups ( |
| Databáze: | OpenAIRE |
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