| Autor: |
Young Kook Kim, Minju Ha, Jinah Yeo, Boseon Kim, V. Narry Kim |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Molecular Cell. 43(6):1005-1014 |
| ISSN: |
1097-2765 |
| DOI: |
10.1016/j.molcel.2011.07.031 |
| Popis: |
Mammalian microRNAs (miRNAs) are highly stable in most cell types, and their decay mechanism remains largely unknown. Here we report that some miRNAs degrade rapidly upon the loss of cell adhesion. When cells are grown at low density or cells are detached by trypsinization or EGTA treatment, mature miR-141 is downregulated while miR-200c from a common primary transcript (pri-miR-200c∼141) remains unaffected. Blockade of transcription by Actinomycin D leads to rapid depletion of miR-141 with a half-life of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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