Podoplanin in Inflammation and Cancer
| Autor: | Lucía Montero-Montero, Ester Martín-Villar, Miguel Quintanilla, Jaime Renart |
|---|---|
| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Quintanilla, Miguel [0000-0002-2124-7657], Renart, Jaime [0000-0001-6620-3706], Quintanilla, Miguel, Renart, Jaime |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Review
Ezrin migration Metastasis Extracellular matrix lcsh:Chemistry Neoplasms Lymphangiogenesis epithelial–mesenchymal transition (EMT) lcsh:QH301-705.5 Spectroscopy platelet Membrane Glycoproteins Epithelial–mesenchymal transition Cell Differentiation C-type lectin-like receptor 2 (CLEC-2) General Medicine ezrin/radixin/moesin (ERM) proteins Computer Science Applications lymphangiogenesis Cell Transformation Neoplastic Disease Susceptibility Signal transduction medicine.symptom Protein Binding Signal Transduction Cell type Embryonic Development Inflammation Biology Catalysis Inorganic Chemistry Immunomodulation Structure-Activity Relationship medicine Animals Humans metastasis Podoplain Physical and Theoretical Chemistry Molecular Biology thrombosis Podoplanin Organic Chemistry Radixin Thrombosis podoplanin Gene Expression Regulation lcsh:Biology (General) lcsh:QD1-999 inflammation Cancer cell Cancer research Carrier Proteins |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 3, p 707 (2019) DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria Universidad Francisco de Vitoria Digital.CSIC. Repositorio Institucional del CSIC instname International Journal of Molecular Sciences DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria |
| ISSN: | 1422-0067 |
| Popis: | This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics. Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the development of the alveoli, heart, and lymphatic vascular system. Emerging evidence indicates that it is also involved in the control of mammary stem-cell activity and biogenesis of platelets in the bone marrow, and exerts an important function in the immune response. Podoplanin expression is upregulated in different cell types, including fibroblasts, macrophages, T helper cells, and epithelial cells, during inflammation and cancer, where it plays important roles. Podoplanin is implicated in chronic inflammatory diseases, such as psoriasis, multiple sclerosis, and rheumatoid arthritis, promotes inflammation-driven and cancer-associated thrombosis, and stimulates cancer cell invasion and metastasis through a variety of strategies. To accomplish its biological functions, podoplanin must interact with other proteins located in the same cell or in neighbor cells. The binding of podoplanin to its ligands leads to modulation of signaling pathways that regulate proliferation, contractility, migration, epithelial⁻mesenchymal transition, and remodeling of the extracellular matrix. In this review, we describe the diverse roles of podoplanin in inflammation and cancer, depict the protein ligands of podoplanin identified so far, and discuss the mechanistic basis for the involvement of podoplanin in all these processes. The work developed in our laboratory was supported by the Spanish Ministry of Science, Innovation, and Universities (grant SAF2017-84183-R). |
| Databáze: | OpenAIRE |
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