Profiling of Potential Antibacterial Compounds of Lactic Acid Bacteria against Extremely Drug Resistant (XDR) Acinetobacter baumannii
| Autor: | Phui Chyng Yap, Jia Jie Woon, Adzzie Shazleen Azman, Cindy Shuan Ju Teh, Sazaly AbuBakar, Vannajan Sanghiran Lee, Hai Yen Lee, Noorfazlin Ayuhan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Acinetobacter baumannii
In silico Pharmaceutical Science Drug resistance infectious diseases Article Analytical Chemistry Microbiology lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound antimicrobial resistance (AMR) lcsh:Organic chemistry Lactobacillales Drug Discovery Drug Resistance Bacterial Physical and Theoretical Chemistry diketopiperazine (DKP) 030304 developmental biology 0303 health sciences biology 030306 microbiology Chemistry Organic Chemistry Malaysia biology.organism_classification Lactic acid Anti-Bacterial Agents lactic acid bacteria Chemistry (miscellaneous) Docking (molecular) Molecular Medicine Gas chromatography–mass spectrometry Antibacterial activity Bacteria |
| Zdroj: | Molecules, Vol 26, Iss 1727, p 1727 (2021) Molecules Volume 26 Issue 6 |
| ISSN: | 1420-3049 |
| Popis: | A total of 20 of isolates of lactic acid bacteria (LAB) were selected and screened for antagonistic activity against clinical strains of 30 clinical isolates of extremely drug-resistant (XDR) Acinetobacter baumannii using the well diffusion assay method. Results showed that 50% of the highly LAB strains possessed inhibitory activity against (up to 66%) of the XDR A. baumannii strains tested. The supernatant of the twenty LAB strains was subjected to gas chromatography mass spectrometry (GCMS) revealed that the common compound found in the active isolates against XDR A. baumannii was 3-Isobutyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, a known potential diketopiperazine group. The molecular docking study against potential antibacterial targets with selected ligands was performed to predict the binding mode of interactions, which is responsible for antibacterial activity. The docking analysis of the potent compounds supported the potential antibacterial activity exhibiting high inhibition constant and binding affinity in silico. |
| Databáze: | OpenAIRE |
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