Estrogen suppression in premenopausal women following 8 weeks of treatment with exemestane and triptorelin versus triptorelin alone
| Autor: | Nicoletta Pirotta, Akintunde Bello, Riccardo Spinelli, Peter Buchan, Maria Gabriella Jannuzzo, Enrico Di Salle |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty medicine.drug_class Estrone Antineoplastic Agents Breast Neoplasms chemistry.chemical_compound Young Adult Breast cancer Exemestane Double-Blind Method Internal medicine medicine Humans Aromatase Aromatase inhibitor Triptorelin Pamoate biology Estradiol business.industry Ovary medicine.disease Triptorelin Androstadienes Endocrinology Oncology chemistry Premenopause Estrogen biology.protein Female Luteinizing hormone business hormones hormone substitutes and hormone antagonists Gonadotropins medicine.drug |
| Zdroj: | Breast cancer research and treatment. 113(3) |
| ISSN: | 1573-7217 |
| Popis: | Introduction Luteinizing hormone-releasing hormone (LHRH) agonists (e.g., triptorelin) reduce ovarian estrogen production in premenopausal women with hormone-sensitive breast cancer. Aromatase inhibitors (e.g., exemestane) inhibit extraovarian production of estrogen and may further reduce circulating estrogens when combined with an LHRH agonist. Methods Healthy premenopausal women were randomized to receive 3.75 mg triptorelin (T) on days 1 and 29 with 25 mg exemestane (EX) or matched placebo once daily for 8 weeks, from day 1 to day 56. The primary objective was to evaluate the effect of T ± EX on estradiol (E2) suppression by comparing the AUCday36–57 for the 2 treatments. Secondary objectives included evaluation of estrone (E1), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) suppression; effects of EX on the T-induced gonadotrophin and estrogen flare; pharmacokinetics (PK); and safety. Results Twenty-eight (14 in each arm) were evaluable for efficacy and PK. Mean plasma estrogen levels (AUCday36–57) were significantly lower for subjects who received T + EX than for subjects who received T alone (20.6 vs. 54.0 pg d/ml [−62%; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink