Cytotoxic, Antimicrobial Activities, Ache And Bche Inhibitory Effects Of Compounds From Tanacetum Chiliophyllum (Fisch & Mey.) Schultz Bip. Var. Oligocephalum (Dc) Sosn. And T. Chiliophyllum (Fisch & Mey.) Schultz Bip. Var. Monocephalum Grierson
| Autor: | Kaan Polatoğlu, Hüsniye Tansel Yalçin, Nezhun Gören, Ayse Nalbantsoy, Yasemin Yücel Yücel |
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| Přispěvatelé: | Polatoğlu, Kaan, Yücel, Yasemin Yücel |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Eupatilin Plant Science Sesquiterpene lactone Antimicrobial Activity Biochemistry Cirsilineol 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Triterpene T. chiliophyllum BChE medicine Ulubelenolide Butyrylcholinesterase chemistry.chemical_classification Chiliophyllum Traditional medicine biology Antimicrobial Coumarin biology.organism_classification 030104 developmental biology chemistry 030220 oncology & carcinogenesis AChE Cytotoxic Activity Agronomy and Crop Science Biotechnology medicine.drug |
| Popis: | WOS:000415919100039 Tanacetum L. species traditionally used for insecticidal purposes as well as in folk medicine for their antitumor, antimicrobial, antifungal activities. In our previous study a novel sesquiterpene lactone and triterpene lactone together with 12 known flavonoids, coumarin and a triterpene were isolated from T. chiliophyllum var. oligocephalum and T. chiliophyllum var. monocephalum extracts which have insecticidal and antimicrobial activity. In this study, cytotoxic, antimicrobial activities and acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory effects of pure compounds isolated from these plants were investigated. The tested compounds showed AChE and BChE inhibition which ranged between 7.20-80.37% and 9.19%-76.99% respectively. The highest AChE and BChE inhibition was observed for ulubelenolide which afforded 80.37% and 76.99% inhibition respectively. The cytotoxic effect of the compounds ranged between 22.34-49.77 mu g/mL IC50 values. Highest cytotoxic activity was observed against MCF-7 and HEK 293 cell line by 5-hydroxy-3', 4', 7-trimethoxy flavone and 5-hydroxy-3', 4', 6,7-tetramethoxyflavone that produced 25.80 +/- 0.17 and 22.34 +/- 0.70 IC50 values respectively. Compounds eupatilin, cirsilineol, 5-hydroxy-3', 4', 7-trimethoxy flavone and ulubelenolide showed significant antimicrobial effect on C. albicans with 7.8 mu g/mL MIC. The new compound ulubelenolide afforded high AChE and BChE inhibition as well as high antifungal activity. In our opinion activity of this substance should be evaluated further against other fungal species. Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK- TBAG 104T306]; State Planning Organization [27-DPT-01-07-01] This research was supported by The Scientific and Technological Research Council of Turkey (TUBITAK- TBAG 104T306) and State Planning Organization (Project No. 27-DPT-01-07-01). We would also like to extend our thanks to AREL (Research and Education Laboratory, Ege University School of Medicine) for laboratory facilities. |
| Databáze: | OpenAIRE |
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