Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology
| Autor: | Mohamed L. Ashour, Ivan R. Green, Ishtiaq Ahmed, Elham Alshammari, Muhammad Saleem, Iftikhar Ali, Muhammad Imran Tousif, Frank Surup, Muhammad Aijaz Anwar, Mamona Nazir, Daijie Wang, Elizbit, Nilufar Z. Mamadalieva, Ahmed M. Ashour, Hidayat Hussain |
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| Přispěvatelé: | Tousif, Muhammad Imran [0000-0002-5777-6112], Surup, Frank [0000-0001-5234-8525], Ali, Iftikhar [0000-0002-5817-8800], Alshammari, Elham [0000-0002-8637-9618], Ashour, Mohamed L. [0000-0002-9270-6267], Ashour, Ahmed M. [0000-0002-2118-0499], Elizbit [0000-0002-9270-6267], Green, Ivan R. [0000-0002-9158-670X], Apollo - University of Cambridge Repository, HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany., Saleem, Muhammad [0000-0001-7704-1087], Mamadalieva, Nilufar Z [0000-0003-1756-3638], Ashour, Mohamed L [0000-0002-9270-6267], Ashour, Ahmed M [0000-0002-2118-0499], Green, Ivan R [0000-0002-9158-670X], Hussain, Hidayat [0000-0002-8654-8127] |
| Rok vydání: | 2021 |
| Předmět: |
antioxidant
meroterpenoids Secondary Metabolism Structural diversity Antineoplastic Agents Review anticancer 010402 general chemistry Microbiology 01 natural sciences Biochemistry Antioxidants chemistry.chemical_compound Alkaloids Anti-Infective Agents Benzoquinones Animals Humans Benzopyrans Phenols Molecular Biology anti-inflammatory chemistry.chemical_classification Biological Products Bacteria biology Terpenes antidiabetic 010405 organic chemistry Fungi Antimicrobial biology.organism_classification QR1-502 Terpenoid Anti-Bacterial Agents Biosynthetic Pathways 0104 chemical sciences Amino acid structural diversity chemistry Chemical diversity Enzyme inhibitory Sesquiterpenes |
| Zdroj: | Biomolecules Switzerland Biomolecules, Vol 11, Iss 957, p 957 (2021) |
| ISSN: | 2218-273X |
| Popis: | Funder: This research was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding Program Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects. |
| Databáze: | OpenAIRE |
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