Indirect treatment comparison of two non-invasive patient-controlled analgesia treatments for acute post-operative pain management
| Autor: | Shweta Takyar, Pamela Palmer, Pablo Katz, Hiltrud Liedgens |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Sufentanil medicine.medical_treatment Fentanyl 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Indirect Treatment medicine Humans health care economics and organizations Pain Postoperative Morphine Patient-controlled analgesia business.industry Non invasive Analgesia Patient-Controlled General Medicine Iontophoresis Acute Pain Analgesics Opioid Tolerability Opioid Anesthesia business 030217 neurology & neurosurgery Tablets medicine.drug |
| Zdroj: | Current Medical Research and Opinion. 33:911-918 |
| ISSN: | 1473-4877 0300-7995 |
| DOI: | 10.1080/03007995.2017.1294560 |
| Popis: | To evaluate the relative clinical efficacy, safety, and tolerability associated with two non-invasive patient-controlled analgesia (PCA) treatments, sufentanil sublingual tablet system (SSTS) and fentanyl iontophoretic patient-controlled transdermal system (PCTS). These two treatments have recently been approved in the EU for the management of acute moderate-to-severe post-operative pain in adult patients.As no head-to-head trials comparing SSTS and PCTS currently exist, indirect treatment comparison (ITC) analyses were conducted to evaluate SSTS or PCTS versus intravenous (IV) morphine PCA.Five studies, four assessing PCTS and one assessing SSTS, were included in this analysis. SSTS had statistical or numerical advantages over PCTS for both patient global assessment (PGA) and healthcare professional global assessment (HPGA) outcomes at all time points investigated. SSTS was also associated with greater patient ease of use (weighted mean difference [WMD]: 0.13; 95% confidence interval [CI]: -0.02-0.28) and a higher patient satisfaction score (WMD: 0.31; 95% CI: 0.05-0.57; p = .019) compared with PCTS. In terms of tolerability, all-cause withdrawals from treatment were reported to be less likely with SSTS (risk ratio: 0.65; 95% CI: 0.42-1.02). No significant differences were observed between SSTS and PCTS in terms of safety and adverse events.In the absence of direct head-to-head data, the combination of promising phase III trial results compared to IV morphine PCA, a SLR comparison against other opioid treatments, and the results of this exploratory analysis present a strong rationale in support of SSTS as a key option for management of post-operative pain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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