Effects of Oral Acute Administration and Subchronic Feeding of Several Levels of D-Psicose in Rats
| Autor: | Tomohiro Tanaka, Mineo Hashiguchi, Ken Izumori, Tatsuhiro Matsuo, Hiroo Suzuki |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Blood Glucose
Diarrhea Male medicine.medical_specialty Administration Oral Medicine (miscellaneous) Adipose tissue Spleen Fructose Median lethal dose Muscle hypertrophy Lethal Dose 50 chemistry.chemical_compound Animal science Oral administration Internal medicine Dietary Carbohydrates medicine Animals Rats Wistar Cecum Triglycerides Nutrition and Dietetics Dose-Response Relationship Drug business.industry Myocardium Body Weight Organ Size Survival Analysis Rats Dose–response relationship Endocrinology medicine.anatomical_structure Liver chemistry Toxicity business |
| Zdroj: | Journal of Nutritional Science and Vitaminology. 48:512-516 |
| ISSN: | 1881-7742 0301-4800 |
| DOI: | 10.3177/jnsv.48.512 |
| Popis: | The effects of oral acute administration and subchronic (34 d) feeding of several levels of D-psicose, a C3-epimer of D-fructose, were studied in rats. In the acute administration test, five groups of eight male Wistar rats (3 wk old) were orally given D-psicose in doses of 8, 11, 14, 17, and 20 g/kg. Three rats receiving 14 g/kg, three rats receiving 17 g/kg and eight rats receiving 20 g/kg of D-psicose died within 2 d after administration. The calculated LD50 values were 16.3 g/kg by the Behrens-Karber method and 15.8 g/kg by the Litchfield-Wilcoxon method. In the subcronic feeding test, eight groups of seven male Wistar rats (3 wk old) were fed diets containing 0 (control), 10, 20, 30, and 40% for 34 d. One rat fed 30% D-psicose diet and five rats fed 40% D-psicose diet died during the experimental period. Body weight gain, food intake and food efficiency were more extensively suppressed by the higher D-psicose diets. The weights of heart, spleen and abdominal adipose tissue were smaller in the order of dietary D-psicose concentration. Cecal weight increased with increasing D-psicose concentration in the diets. Cecal hypertrophy was observed in rats fed 10-40% D-psicose diets. These results suggest that D-psicose differs in nutritional characteristics from D-glucose or D-fructose. The feeding of diets extremely high in D-psicose seems to be harmful to the intestinal tract. |
| Databáze: | OpenAIRE |
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