Improvement in arterial stiffness (pOpmètre®) after bariatric surgery. Results from a prospective study
| Autor: | Claire Blanchard, S. Frey, Bertrand Cariou, Eric Mirallié, David Jacobi, Matthieu Pichelin |
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| Přispěvatelé: | Institut des Maladies de l'Appareil Digestif, Université de Nantes (UN), Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Adolescent [SDV]Life Sciences [q-bio] Endocrinology Diabetes and Metabolism Bariatric Surgery 030209 endocrinology & metabolism Young Adult 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Endocrinology Risk Factors Humans Medicine Postoperative Period Prospective Studies Prospective cohort study Pulse wave velocity Pathological Aged business.industry Surrogate endpoint General Medicine Middle Aged medicine.disease Obesity Obesity Morbid Surgery Mean blood pressure Cardiovascular Diseases 030220 oncology & carcinogenesis Arterial stiffness Female business Follow-Up Studies |
| Zdroj: | Annales d'Endocrinologie Annales d'Endocrinologie, Elsevier Masson, 2020, 81, pp.44-50. ⟨10.1016/j.ando.2020.01.002⟩ |
| ISSN: | 0003-4266 |
| DOI: | 10.1016/j.ando.2020.01.002 |
| Popis: | Background Arterial stiffness (AS) is an independent predictor of cardiovascular risk, and could be used as a surrogate marker of improvement in cardiovascular risk following bariatric surgery. The aim of this study was to compare AS before and after surgery. Methods One hundred and thirty-four patients undergoing bariatric surgery between May 2016 and January 2019 were prospectively included. AS was measured on pulse wave velocity (PWV) with the pOpmetre® device pre- and postoperatively. The main endpoint was change in PWV between baseline and 3 months post-surgery. Results Overall, mean PWV was 6.87 m/s preoperatively and 6.71 m/s at 3 months (P = 0.7148). Patients with pathologic PWV (> 2 standard deviations from expected value for age) showed significant improvement at 3 months (31 patients; 10.1 m/s preoperatively vs 7.5 m/s at 3 months; P = 0.007). These results did not correlate with improvement in other clinical or biological parameters following surgery (excess weight loss, mean blood pressure, fasting blood glucose, waist circumference, body composition). Conclusion These results suggest that pathological arterial stiffness may resolve following bariatric surgery independently of the other factors influencing cardiovascular risk in obesity. |
| Databáze: | OpenAIRE |
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