‘Old' and ‘new' drugs for the treatment of cancer pain
| Autor: | Emanuela Dell'Aquila, Nicola Papapietro, Daniele Santini, Bruno Vincenzi, Marco Russano, Carla Ripamonti, Gaetano Lanzetta, Vincenzo Denaro, Olga Venditti, Giuseppe Tonini |
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| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
medicine.medical_specialty business.industry Breakthrough Pain Treatment outcome Alternative medicine MEDLINE Analgesic ladder General Medicine World health Surgery Analgesics Opioid Treatment Outcome Neoplasms Expert opinion Family medicine Practice Guidelines as Topic medicine Humans Pain Management Severe pain Pharmacology (medical) business Cancer pain Pain Measurement |
| Zdroj: | Expert Opinion on Pharmacotherapy. 14:425-433 |
| ISSN: | 1744-7666 1465-6566 |
| DOI: | 10.1517/14656566.2013.774375 |
| Popis: | More than 20 years ago the World Health Organization (WHO) published the booklet 'Cancer Pain Relief', including the fundamentals and clear principles, which was summarized in five simple sentences: 'by mouth', 'by the clock', 'by the ladder', 'for the individual' and 'attention to detail'. Over the years, several modifications to the analgesic ladder have been proposed, as the addition of two further steps, related to the switch of opioid and/or non-invasive route of administration, and to the use of invasive approaches, or again the skip of the second step; nevertheless the educational value and benefits related to the worldwide dissemination are of paramount importance.To date, all the guidelines are inspired by the strategy of WHO; below some of the most important international guidelines published in the last two years are compared, particularly as regards the criteria of choice of opioids for moderate/severe pain.The discussion on the role of the second step of the WHO analgesic ladder is still open. The challenge for new formulations of 'old' opioids will be to better manage cancer pain, with more tailored efficacy and possibly less side effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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