Salmonella Typhimurium Diarrhea Reveals Basic Principles of Enteropathogen Infection and Disease-Promoted DNA Exchange
| Autor: | Bidong D. Nguyen, Wolf-Dietrich Hardt, Sandra Y. Wotzka |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Diarrhea
Salmonella typhimurium 0301 basic medicine Salmonella Gene Transfer Horizontal 030106 microbiology Virulence medicine.disease_cause Microbiology 03 medical and health sciences Antibiotic resistance Virology medicine Intestinal Mucosa Pathogen biology Transmission (medicine) biology.organism_classification Immunity Innate 3. Good health Interspersed Repetitive Sequences Vaccination 030104 developmental biology Salmonella enterica Host-Pathogen Interactions Salmonella Infections Immunology Parasitology Antibody Epithelium Inflammasome Inflammation Microbiota Mucosa NLRC4 Phage Plasmid Secretory IgA medicine.symptom |
| Zdroj: | Cell host & microbe Cell Host & Microbe, 21 (4) |
| ISSN: | 1931-3128 |
| Popis: | Despite decades of research, efficient therapies for most enteropathogenic bacteria are still lacking. In this review, we focus on Salmonella enterica Typhimurium (S. Typhimurium), a frequent cause of acute, self-limiting food-borne diarrhea and a model that has revealed key principles of enteropathogen infection. We review the steps of gut infection and the mucosal innate-immune defenses limiting pathogen burdens, and we discuss how inflammation boosts gut luminal S. Typhimurium growth. We also discuss how S. Typhimurium-induced inflammation accelerates the transfer of plasmids and phages, which may promote the transmission of antibiotic resistance and facilitate emergence of pathobionts and pathogens with enhanced virulence. The targeted manipulation of the microbiota and vaccination might offer strategies to prevent this evolution. As gut luminal microbes impact various aspects of the host's physiology, improved strategies for preventing enteropathogen infection and disease-inflicted DNA exchange may be of broad interest well beyond the acute infection. |
| Databáze: | OpenAIRE |
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