Intra-arterial or intravenous thrombolysis for acute ischemic stroke? The SYNTHESIS pilot trial
| Autor: | Ciccone, A, Valvassori, L, Ponzio, M, Ballabio, E, Gasparotti, R, Sessa, M, Tiraboschi, P, Sterzi, R, Candelise, L, Del Zoppo, G, Sandercock, P, Cantisani, T, Coppola, C, Gatti, A, Guccione, A, Santilli, I, Jann, S., Protti, A., Rizzone, Mario Giorgio, Boccardi, E, Guidotti, M., Checcarelli, N, Muscia, F, Martegani, A, Magoni, M., Costa, A., Pavia, M, Scomazzoni, F. |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
thrombolysis Time Factors ischemic stroke randomized controlled trial medicine.medical_treatment Pilot Projects law.invention Brain Ischemia Randomized controlled trial law Intra arterial Medicine Humans Infusions Intra-Arterial Thrombolytic Therapy Thrombus Adverse effect Infusions Intravenous Acute ischemic stroke Aged business.industry Pilot trial General Medicine Thrombolysis Middle Aged medicine.disease Stroke Survival Rate Treatment Outcome Anesthesia Tissue Plasminogen Activator Ischemic stroke Feasibility Studies Surgery Female Neurology (clinical) business Follow-Up Studies |
| Popis: | OBJECTIVE To assess the feasibility, safety and preliminary efficacy of intra-arterial thrombolysis (IAT) compared with standard intravenous thrombolysis (IVT) for acute ischemic stroke. METHODS Eligible patients with ischemic stroke, who were devoid of contraindications, started IVT within 3 h or IAT as soon as possible within 6 h. Patients were randomized within 3 h of onset to receive either intravenous alteplase, in accordance with the current European labeling, or up to 0.9 mg/kg intra-arterial alteplase (maximum 90 mg), over 60 min into the thrombus, if necessary with mechanical clot disruption and/or retrieval. The purpose of the study was to determine the proportion of favorable outcome at 90 days. Safety endpoints included symptomatic intracranial hemorrhage (SICH), death and other serious adverse events. RESULTS 54 patients (25 IAT) were enrolled. Median time from stroke onset to start to treatment was 3 h 15 min for IAT and 2 h 35 min for IVT (p |
| Databáze: | OpenAIRE |
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