Modulation of neuropeptide Y levels is impaired in crack withdrawal patients
| Autor: | Anne Orgler Sordi, Jaqueline Bohrer Schuch, Daiane Silvello, Juliana Nichterwitz Scherer, Lisia von Diemen, Fabiana Galland, Karina Proença Ligabue, Fernanda Hansen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Future studies Cortisol awakening response Hydrocortisone medicine.drug_class media_common.quotation_subject RC435-571 crack cocaine Anxiolytic 03 medical and health sciences Cocaine-Related Disorders stress 0302 clinical medicine Internal medicine mental disorders Medicine Humans 0501 psychology and cognitive sciences Neuropeptide Y Cortisol level Morning media_common Psychiatry Inpatients business.industry Addiction 05 social sciences General Medicine Middle Aged Neuropeptide Y receptor Pathophysiology humanities 030227 psychiatry Substance Withdrawal Syndrome Psychiatry and Mental health Endocrinology Crack Cocaine addiction business Stress Psychological 050104 developmental & child psychology |
| Zdroj: | Trends in Psychiatry and Psychotherapy, Volume: 42, Issue: 2, Pages: 147-152, Published: 17 JUL 2020 Trends in Psychiatry and Psychotherapy, Vol 42, Iss 2, Pp 147-152 (2020) Trends in Psychiatry and Psychotherapy v.42 n.2 2020 Trends in Psychiatry and Psychotherapy Sociedade de Psiquiatria do Rio Grande do Sul instacron:APRGS |
| Popis: | Introduction The dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has a key role in drug addiction susceptibility. In addition to the well-known relationship between cortisol and the HPA axis, other molecules are involved with stress response and could modify the HPA activation, such as the neuropeptide Y (NPY), which has anxiolytic proprieties. There are few studies evaluating the effect of NPY levels on addiction, especially in crack cocaine dependence. Objective To evaluate NPY in crack users during early withdrawal to determine its relationship with drug use and cortisol levels. Methods We analyzed 25 male inpatient crack users. Serum NPY levels were measured at admission and discharge (mean of 24 days). Morning salivary cortisol was measured at admission. Results Serum NPY levels at admission and discharge were very similar. Lower NPY levels at discharge were associated with higher lifetime crack use. Also, a negative correlation was found between morning cortisol and delta NPY (NPY discharge – NPY admission). Conclusion These preliminary findings indicate that crack use influences the modulation of NPY levels and modifies stress response. The NPY pathway may play an important role in the pathophysiology of crack addiction, and the anxiolytic effect of NPY may be impaired in crack users. Future studies should consider NPY as a measurable indicator of the biological state in addiction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|