The relationship between negative symptoms and cognitive functioning in patients at clinical high risk for psychosis
| Autor: | Letizia Leanza, Laura Egloff, Christina Andreou, Erich Studerus, Martina Uttinger, Anita Riecher-Rössler, Sarah Ittig, Katharina Beck, Ulrike Heitz |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Psychosis Alogia Asociality Neuropsychological Tests 03 medical and health sciences Young Adult 0302 clinical medicine Cognition Risk Factors medicine Verbal fluency test Humans Prospective Studies Scale for the Assessment of Negative Symptoms Biological Psychiatry medicine.diagnostic_test business.industry Anhedonia Neuropsychological test medicine.disease 030227 psychiatry Psychiatry and Mental health Cross-Sectional Studies Psychotic Disorders Female medicine.symptom business Cognition Disorders Neurocognitive 030217 neurology & neurosurgery Clinical psychology |
| DOI: | 10.5451/unibas-ep70694 |
| Popis: | Negative symptoms and neurocognitive performance have been reported to be negatively associated in patients with emerging psychosis. However, most previous studies focused on patients with frank psychosis and did not differentiate between subdomains of negative symptoms. Hence, we aimed to elucidate the specific relationship between negative symptoms and cognitive functioning in patients at clinical high risk (CHR) for psychosis. Data from 154 CHR patients collected within the prospective Fruherkennung von Psychosen (FePsy) study were analyzed. Negative symptoms were assessed with the Scale for the Assessment of Negative Symptoms (SANS) and cognitive functioning with an extensive neuropsychological test battery. Regression analyses revealed significant negative associations between negative symptoms and cognitive functioning, particularly in the domains of nonverbal intelligence and verbal fluency. When analyzing each negative symptom domain separately, alogia and asociality/anhedonia were significantly negatively associated with nonverbal intelligence and alogia additionally with verbal fluency. Overall, our results in CHR patients are similar to those reported in patients with frank psychosis. The strong negative association between verbal fluency and negative symptoms may be indicative of an overlap between these constructs. Verbal fluency might have a strong influence on the clinical impression of negative symptoms (particularly alogia) and vice versa. |
| Databáze: | OpenAIRE |
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