Maternal care modulates transgenerational effects of endocrine-disrupting chemicals on offspring pup vocalizations and adult behaviors
| Autor: | Andrea C. Gore, Shafaqat Rahman, Krittika Krishnan, David Crews, Asbiel Hasbum, Lindsay M. Thompson, Daniel Morales |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Aroclors Offspring Physiology Anxiety Endocrine Disruptors Biology Article Rats Sprague-Dawley 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Endocrinology Transgenerational epigenetics Pregnancy Animals Endocrine system Sexual Maturation Vinclozolin Maternal Behavior Oxazoles Behavior Animal Endocrine and Autonomic Systems Polychlorinated biphenyl Polychlorinated Biphenyls Rats 030227 psychiatry Animals Newborn chemistry Prenatal Exposure Delayed Effects Female Sesame oil Vocalization Animal 030217 neurology & neurosurgery |
| Zdroj: | Hormones and Behavior. 107:96-109 |
| ISSN: | 0018-506X |
| DOI: | 10.1016/j.yhbeh.2018.12.009 |
| Popis: | Endocrine-disrupting chemicals (EDCs) can act upon a developing organism to change its endocrine health and behavior in adulthood. Beyond actions on the exposed individuals, transgenerational effects of several EDCs have been reported. This study assessed the combinatorial impact of EDC-altered maternal care and transgenerational inheritance on F3 male and female offspring. Pregnant rats were exposed to EDCs with different modes of action: the weakly estrogenic polychlorinated biphenyl (PCB) mixture Aroclor 1221, the anti-androgenic fungicide vinclozolin (VIN), or the vehicle (6% dimethylsulfoxide in sesame oil; VEH) during embryonic development. The F1 male and female offspring were bred through the paternal- or maternal-lineage with untreated partners to generate F2 offspring. This process was repeated through both maternal and paternal lineages to create the F3 generation. Maternal care of F2 dams towards their F3 offspring was altered in a lineage-dependent manner, particularly in PCB paternal-lineage animals. When F3 pups were recorded for ultrasonic vocalizations (USVs) following separation from the mother, the rate of neonatal USVs in F3 offspring were decreased in PCB paternal-lineage pups. In adulthood, anxiety-like behaviors of the F3 rats were tested, with only small effects of EDCs detected. These interactions of maternal behaviors and EDC effects across generations, especially via the paternal lineage, has implications for health and environmental responses in wildlife and humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect