Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease
| Autor: | Remuzgo-Martínez, Sara, Genre, Fernanda, Pulito-Cueto, Verónica, Atienza-Mateo, Belén, Mora Cuesta, Víctor Manuel, Iturbe Fernández, David, Fernández Rozas, Sonia María, Lera-Gómez, Leticia, Alonso Lecue, Pilar, Ussetti, María Piedad, Laporta, Rosalía, Berastegui García, Cristina, Solé, Amparo, Pérez González, Virginia Luz, De Pablo Gafas, Alicia, Gualillo, Oreste, Cifrián, José Manuel, López-Mejías, Raquel, Gonzalez-Gay, MA, Universitat Autònoma de Barcelona |
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| Přispěvatelé: | Institut Català de la Salut, Vall d'Hebron Barcelona Hospital Campus, Universidad de Cantabria |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
idiopathic interstitial pneumonia
medicine.medical_specialty Pulmons - Malalties - Aspectes genètics Respiratory Tract Diseases::Lung Diseases::Lung Diseases Interstitial [DISEASES] QH301-705.5 Medicine (miscellaneous) Interstitial lung disease Gastroenterology General Biochemistry Genetics and Molecular Biology Pulmonary function testing Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Receptor Protein-Tyrosine Kinases::Receptors Vascular Endothelial Growth Factor [CHEMICALS AND DRUGS] Lung Disorder 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Genotype Proteïnes quinases - Receptors medicine Other subheadings::Other subheadings::/genetics [Other subheadings] Genetics genetics Idiopathic interstitial pneumonia Biology (General) health care economics and organizations interstitial lung disease vascular endothelial growth factor business.industry Otros calificadores::Otros calificadores::/genética [Otros calificadores] Haplotype Biomarker respiratory system medicine.disease respiratory tract diseases Vascular endothelial growth factor 030228 respiratory system chemistry enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales [ENFERMEDADES] 030220 oncology & carcinogenesis Biomarker (medicine) enzimas y coenzimas::enzimas::transferasas::fosfotransferasas::fosfotransferasas (grupo alcohol aceptor)::proteína cinasas::proteína-tirosina cinasas::receptores proteína-tirosina cinasas::receptores del factor de crecimiento del endotelio vascular [COMPUESTOS QUÍMICOS Y DROGAS] biomarker business |
| Zdroj: | Biomedicines, Vol 9, Iss 458, p 458 (2021) Biomedicines Volume 9 Issue 5 Scientia Biomedicines . 2021 Apr 22;9(5):458 UCrea Repositorio Abierto de la Universidad de Cantabria Universidad de Cantabria (UC) Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
| ISSN: | 2227-9059 |
| Popis: | Biomarker; Interstitial lung disease; Vascular endothelial growth factor Biomarcador; Malaltia pulmonar intersticial; Factor de creixement endotelial vascular Biomarcador; Enfermedad pulmonar intersticial; Factor de crecimiento vascular endotelial The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP patients was found. None of the VEGF polymorphisms were associated with VEGF levels. In conclusion, our results suggest that VEGF does not seem to play a relevant role in ILD, although rs1570360 may influence the severity of ILD in women and a worse outcome in IIP patients. This research was partially supported by a grant from Spanish Society of Pulmonology and Thoracic Surgery (SEPAR 474-2017). S.R.-M. was supported by funds of the RETICS Program (RD16/0012/0009) from the “Instituto de Salud Carlos III” (ISCIII), co-funded by the European Regional Development Fund. V.P.-C. was supported by a pre-doctoral grant from IDIVAL (PREVAL 18/01). B.A.-M. was recipient of a “López Albo” post-residency program funded by Servicio Cántabro de Salud. L.L.-G. was supported by funds from IDIVAL (INNVAL 20/06). O.G. was beneficiary of a grant funded by Xunta de Galicia, Consellería de Educación, Universidade e Formación Profesional and Consellería de Economía, Emprego e Industria (GAIN), GPC IN607B2019/10. R.L.-M. was a recipient of a Miguel Servet type I program fellowship from the ISCIII, co-funded by the ESF, “Investing in your future” (grant CP16/00033). |
| Databáze: | OpenAIRE |
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