Sonographic features of invasive ductal breast carcinomas predictive of malignancy grade

Autor:	Tushar Chandra, Kanika Gupta, Maya Menon, Aruna R Patil, Meenakshisundaram Kumaresan, Bhuvaneswari Venkatesan
Rok vydání:	2018
Předmět:	medicine.medical_specialty histological grade BI-RADS Breast imaging R895-920 030204 cardiovascular system & hematology Malignancy 030218 nuclear medicine & medical imaging Medical physics. Medical radiology. Nuclear medicine 03 medical and health sciences 0302 clinical medicine Biopsy invasive ductal carcinoma medicine Chi-square test Radiology Nuclear Medicine and imaging skin and connective tissue diseases medicine.diagnostic_test ultrasound business.industry Breast Imaging Ultrasound Echogenicity medicine.disease breast malignancy Histopathology Radiology business
Zdroj:	The Indian Journal of Radiology & Imaging Indian Journal of Radiology and Imaging, Vol 28, Iss 01, Pp 123-131 (2018)
ISSN:	1998-3808 0971-3026
DOI:	10.4103/ijri.ijri_257_17
Popis:	Context: Assessment of individual sonographic features provides vital clues about the biological behavior of breast masses and can assist in determining histological grade of malignancy and thereby prognosis. Aims: Assessment of individual sonographic features of biopsy proven invasive ductal breast carcinomas as predictors of malignancy grade. Settings and Design: A retrospective analysis of sonographic findings of 103 biopsy proven invasive ductal breast carcinomas. Materials and Methods: Tumor characteristics on gray-scale ultrasound and color flow were assessed using American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) Atlas Fifth Edition. The sonographic findings of masses were individually correlated with their histopathologic grades. Statistical Analysis Used: Chi square test, ordinal regression, and Goodman and Kruskal tau test. Results: Breast mass showing reversal/lack of diastolic flow has a high probability of belonging to histological high grade tumor (β 1.566, P 0.0001). The masses with abrupt interface boundary are more likely grade 3 (β 1.524, P 0.001) in comparison to masses with echogenic halos. The suspicious calcifications present in and outside the mass is a finding associated with histologically high grade tumors. The invasive ductal carcinomas (IDCs) with complex solid and cystic echotexture are more likely to be of high histological grade (β 1.146, P 0.04) as compared to masses with hypoechoic echotexture. Conclusions: Certain ultrasound features are associated with tumor grade on histopathology. If the radiologist is cognizant of these sonographic features, ultrasound can be a potent modality for predicting histopathological grade of IDCs of the breast, especially in settings where advanced tests such as receptor and molecular analyses are limited.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9afe6c4b4eefb70abefa4717bc79897 https://doi.org/10.4103/ijri.ijri_257_17 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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