Effect of chronic estradiol treatment on dopamine concentrations in discrete brain nuclei of hypophysectomized female rats
| Autor: | Michel Daigle, T. Di Paolo, André Dupont |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Hypophysectomy medicine.drug_class Dopamine medicine.medical_treatment Hypothalamus Nucleus Accumbens Internal medicine medicine Animals Castration Afferent Pathways Estradiol Chemistry General Neuroscience Dopaminergic Brain Rats Inbred Strains Amygdala Corpus Striatum Frontal Lobe Rats Substantia Nigra Endocrinology Steroid therapy Estrogen Pituitary Gland Ovariectomized rat Female Estradiol treatment medicine.drug |
| Zdroj: | Neuroscience Letters. 32:295-300 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(82)90310-x |
| Popis: | We investigated the effect of chronic estradiol treatment on dopamine concentrations in 14 discrete brain nuclei of hypophysectomized rats. Estrogen treatment reduced dopamine concentrations in nigrostriatal and mesolimbic dopaminergic systems of hypophysectomized and ovariectomized rats compared to hypophysectomized controls while the opposite was observed in tuberoinfundibular nuclei. However, hypophysectomized rats had significantly higher dopamine concentrations compared to ovariectomized animals is nigrostriatal and mesolimbic nuclei while lower levels were found in tuberoinfundibular structures. Thus, estradiol treatment has an effect on brain dopamine concentrations independently of the pituitary. Furthermore, this steroid treatment corrects the effects produced by hypophysectomy on brain dopamine concentrations. |
| Databáze: | OpenAIRE |
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