Marine Food Protection in Testicular Damages Caused by Diabetes Mellitus
| Autor: | Joaqvim Evencio Neto, Vitor Caiaffo, Fabrício Bezerra de Sá, Belisa Duarte Ribeiro de Oliveira, Voldemiro Amaro da Silva Junior |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty 040301 veterinary sciences Testicular Disorder Endocrinology Diabetes and Metabolism medicine.medical_treatment Physical exercise Apoptosis Testicle medicine.disease_cause 030226 pharmacology & pharmacy Testicular Diseases Antioxidants Diabetes Mellitus Experimental 0403 veterinary science Diabetes Complications 03 medical and health sciences 0302 clinical medicine Endocrinology Erectile Dysfunction Internal medicine Diabetes mellitus Testis medicine Animals Humans business.industry Insulin Metabolic disorder 04 agricultural and veterinary sciences medicine.disease Spermatozoa Diet Oxidative Stress Erectile dysfunction medicine.anatomical_structure Seafood business Oxidative stress |
| Zdroj: | Current diabetes reviews. 13(6) |
| ISSN: | 1875-6417 |
| Popis: | Introduction Diabetes Mellitus (DM) is a chronic hyperglycemic condition with major health concern on a global scale. DM is a heterogeneous metabolic disorder stemming from defective insulin secretion and/or resistance to action of insulin. Diabetes is recognized cause of male sexual dysfunction and affects reproductive function in humans and animal models, including the endocrine control of spermatogenesis, erectile dysfunction and ejaculation disorder. Testicular disorder is characteristically marked by reductions of testicle weight, sperm count and motility, as well as changes in the morphology of the seminiferous epithelium. Altered testosterone level is another characteristic of diabetic animals. Studies have demonstrated that DM increases apoptosis in germ cells and lead to the interruption of spermatogenesis, mainly by exerting an influence on Bcl-2 protein and cysteinedependent aspartate-directed proteases. DM also increases oxidative stress in testicular cells and excessive production of radical oxygen species has been demonstrated. Several strategies can be used as means of prevention and/or treatment for diverse types of damage to testicles by DM such as regular physical exercise, stress reduction and food intake of substances with antioxidant potential. A hypoglycemic and antioxidant potential diet, in particular, the seafood, can be a valuable instrument of guard against damage caused by DM, both the systemic level as testicular level. The objective of this review is to summarize evidences that study the antioxidant, anti-inflammatory and anti-apoptosis role of seafood in testicles morphology damages induced by diabetes mellitus. Conclusion The seafood plays an antioxidant, anti-inflammatory and anti-apoptosis role in testicles morphology damages induced by diabetes mellitus. This relation seems to be associated with Omega-3 and carotenoids (astaxanthin) levels. |
| Databáze: | OpenAIRE |
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