CRISPR-based metabolic editing: Next-generation metabolic engineering in plants
| Autor: | Masoumeh Zeinali, Mohammad Sabzehzari, Mohammad Reza Naghavi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Gene Editing CRISPR/Cpf1 General Medicine Computational biology Biology First generation Metabolic engineering 03 medical and health sciences Plant Breeding 030104 developmental biology 0302 clinical medicine Genome editing Metabolic Engineering 030220 oncology & carcinogenesis Genetics CRISPR CRISPR-Cas Systems |
| Zdroj: | Gene. 759 |
| ISSN: | 1879-0038 |
| Popis: | Plants generate many secondary metabolites, so called phyto-metabolites, which can be used as toxins, dyes, drugs, and insecticides in bio-warfare plus bio-terrorism, industry, medicine, and agriculture, respectively. To 2013, the first generation metabolic engineering approaches like miRNA-based manipulation were widely adopted by researchers in biosciences. However, the discovery of the clustered regularly interspaced short palindromic repeat (CRISPR) genome editing system revolutionized metabolic engineering due to its unique features so that scientists could manipulate the biosynthetic pathways of phyto-metabolites through approaches like miRNA-mediated CRISPR-Cas9. According to the increasing importance of the genome editing in plant sciences, we discussed the current findings on CRISPR-based manipulation of phyto-metabolites in plants, especially medicinal ones, and suggested the ideas to phyto-metabolic editing. |
| Databáze: | OpenAIRE |
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