Effect of interleukin 10 on the release of the CXC chemokines growth related oncogene GRO-α and epithelial cell-derived neutrophil activating peptide (ENA)-78 during human endotoxemia
| Autor: | Tom van der Poll, Dasja Pajkrt, Dariusz P. Olszyna, Sander J. H. van Deventer |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Lipopolysaccharides Male Chemokine CXCL5 Lipopolysaccharide Neutrophils Chemokine CXCL1 Immunology Peripheral blood mononuclear cell chemistry.chemical_compound Double-Blind Method Humans Immunology and Allergy Interleukin 8 Growth Substances Chemotactic Factors Oncogene Chemistry Interleukin-8 Interleukin Chemotaxis Endotoxemia In vitro Interleukin-10 Interleukin 10 Injections Intravenous Leukocytes Mononuclear Cancer research Intercellular Signaling Peptides and Proteins lipids (amino acids peptides and proteins) Chemokines CXC |
| Zdroj: | Immunology letters, 78(1), 41-44. Elsevier |
| ISSN: | 0165-2478 |
| Popis: | Pretreatment with interleukin (IL)-10 inhibited the release of growth-related oncogene GRO-alpha but not of epithelial-cell derived neutrophil activating protein (ENA)-78, after injection of lipopolysaccharide (LPS) into healthy humans. In vitro, IL-10 dose-dependently attenuated LPS-induced release of both GRO-alpha and ENA-78 in whole blood and in cultures of isolated polymorphonuclear and mononuclear cells. |
| Databáze: | OpenAIRE |
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