Experimental autoimmune encephalomyelitis in the rat
| Autor: | Mark Mannie, Robert H. Swanborg, Jolie A. Stepaniak |
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| Rok vydání: | 2009 |
| Předmět: |
Cell Extracts
Biomedical Research Encephalomyelitis Autoimmune Experimental T-Lymphocytes Immunology Guinea Pigs Autoimmunity Myelin Basic Protein Rats Inbred Strains T-Cell Antigen Receptor Specificity Adoptive Transfer Autoantigens Rats Myelin-Associated Glycoprotein Spinal Cord Animals Immunization Myelin-Oligodendrocyte Glycoprotein Myelin Proteolipid Protein Myelin Proteins Demyelinating Diseases |
| Zdroj: | Current protocols in immunologyLiterature Cited. |
| ISSN: | 1934-368X |
| Popis: | There are several diverse rat models of experimental autoimmune encephalomyelitis (EAE) that can be used to investigate the pathogenesis and regulation of autoimmunity against CNS myelin. The disease course of these models ranges from an acute monophasic disease with limited demyelination to a chronic relapsing or chronic progressive course marked by severe demyelination. These models enable the study of encephalitogenic T cells and demyelinating antibody specific for major neuroantigens such as myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), or proteolipid protein (PLP), among other important CNS autoantigens. Overall, this unit provides an overview of common methods for induction of active and passive EAE, assessment and analysis of clinical disease, preparation and purification of myelin basic protein, and derivation of neuroantigen-specific rat T cell lines. This unit also provides a brief discussion of the basic characteristics of these models. |
| Databáze: | OpenAIRE |
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